Key Difference – Pathology vs Pathophysiology

Pathology and also pathophysiology are 2 areas that examine the problems of conditions in organisms. The major difference in between pathology and pathophysiology is that pathology is a clinical discipline, describing the physical problems observed within an organism throughout the illness whereas pathophysiology is a biological technique, describing the transforms of the biochemical processes or mechanisms, operating within an organism during the disease. The causes of a certain disease are stupassed away in etiology. The symptoms of the illness are studied in pathology. The useful changes within the organism throughout the condition is stupassed away in pathophysiology.

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Key Areas Covered

1. What is Pathology – Definition, Facts, Types 2. What is Pathophysiology – Definition, Facts, Tools 3. What are the Similarities Between Pathology and also Pathophysiology – Overview of Common Features 4. What is the Difference Between Pathology and Pathophysiology – Comparikid of Key Differences

Key Terms: Biochemical Processes, Cytopathology, Molecular Pathology, Pathophysiology, Surgical Pathology


What is Pathology

Pathology refers to the study of vital nature of illness. It is a medical self-control used in the diagnosis of a condition through the physical examicountry of surgically-rerelocated tconcerns (biopsy samples), organs, body fluids, or the entirety body (autopsy). The appearance of the cells and also the gross anatomical makeup is studied in the time of pathology. The causes of the illness, disease device, and the level of the disease are likewise stupassed away in the time of pathology. Necrosis (fatality of cells or tissues), neoplasia (abnormal new cell growth), cellular adaptation to injury, inflammation, and wound healing can be stupassed away throughout the anatomical examination of the samples. Majority of cancers are diagnosed during the pathological examicountry of the body. The neurofibrillary tangles in the hippocampus that can be observed in Alzheimer-associated pathology are shown in number 1.


Figure 1: Neurofibrillary Tangles(dark purple) in the Hippocampus

Surgical pathology, cytopathology, and also molecular pathology are the 3 main locations of pathology. The tissues are examined under the microscopic lense (histologic) or via the naked eye (gross) in surgical pathology. Autopsy is a type of surgical pathology in which the totality body is examined to uncover the reason and also manner of death. During cytopathology, complimentary cells or tissue fragments are oboffered for the diagnosis of cancers, contagious conditions or inflammatory problems. In molecular pathology, the molecules in the body fluids, tworries, and organs are examined via PCR, microrange, hybridization, antibody-based immunofluorescence assays, and so on.

What is Pathophysiology

Pathophysiology refers to the research of disordered physiological procedures connected via illness. Physiology explains the biochemical mechanisms of the body under normal conditions. Pathophysiology describes the abnormal biochemical problems of the body led to by the condition. The deficiency/absence of enzymes in a biochemical pathmethod of usual amino acid metabolism of phenylalanine and tyrosine, which reasons abnormal metabolites or conditions such as phenylketonuria and alkaptonuria is displayed in figure 2.


Figure 2: Pathophysiology of Metabolic Disorders

A disease might influence the functioning of the body by suggests of biochemical and physical elements. By measuring the levels of biochemical compounds such as sodium, potassium, bicarbonate, glucose, creatinine, amino acids, etc., the adjust in the physiology of the body because of the disease have the right to be examined.

Similarities Between Pathology and Pathophysiology

Pathology and also pathophysiology are two areas that examine the diseases of a specific organism.Both pathology and pathophysiology are important in the identification and also treating a disease.

Difference Between Pathology and Pathophysiology


Pathology: Pathology refers to the research of necessary nature of illness.

Pathophysiology: Pathophysiology describes the study of disordered physiological processes connected via conditions.

Type of Study

Pathology: The physical problems of an organism in the time of the condition are stupassed away in pathology.

Pathophysiology: The biochemical changes of the body are stupassed away in pathophysiology.


Pathology: Pathology is a medical self-control.

Pathophysiology: Pathophysiology is a biological discipline.


Pathology: Direct observation of the symptoms of the condition are studied in the time of pathology.

Pathophysiology: Experimental dimensions are stupassed away throughout pathophysiology.


Pathology: Gross and also microscopic examination of tissues, organs, and also the entirety body is done in pathology.

Pathophysiology: The levels of biochemical compounds such as sodium, potassium, bicarbonate, glucose, and also creatinine are examined in pathophysiology.


Pathology and pathophysiology are 2 types of researches that focus on various problems of an organism during a condition. The symptoms of the disease are stupassed away in pathology while the biochemical transforms of the body are studied in pathophysiology. The main difference in between pathology and also pathophysiology is the kind of conditions studied in each location.

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1. “What is Pathology?” DEPARTMENT OF PATHOLOGY, 28 Jan. 2015, Available here.

Image Courtesy:

1. “Neurofibrillary tangles in the Hippocampus of an old perchild with Alzheimer-related pathology, HE 2” By Patho – Own work (CC BY-SA 3.0) via Commons Wikimedia2. “Pathophysiology of metabolic disorders of phenylalanine and tyrosine” By LHcheM – Own work (CC BY-SA 3.0) using Commons Wikimedia